Receptor nerve cells in various body organs and beneath the skin operate as the point at which pain first manifests. When you are ill, injured, or dealing with another type of problem, these receptor cells send signals to the spinal cord, which then delivers the signal to the brain. Painkillers reduce or block these messages before they get to the brain. Anything that hurts might be anything from a minor annoyance, like a headache, to severe and urgent pain, like the discomfort of kidney stones or the chest agony that occurs with a heart attack. Subacute pain lasts for a few weeks or months, chronic pain lasts for more than three months, and acute pain is recent. Chronic pain is one of the most expensive medical conditions. Increased medical expenses, lost income, decreased productivity, compensation payments, and legal fees are just a few of the negative economic implications of chronic pain.

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