Receptor nerve cells are where pain starts beneath the skin and in many body organs. When you are sick, hurt, or dealing with another problem, these receptor cells send signals to the spinal cord, which then delivers the signal to the brain. Painkillers suppress or stop these messages before they reach the brain. agony can be anything from a minor annoyance, such as a headache, to something excruciating and urgent, such as the agony of kidney stones or the chest pain associated with a heart attack. Chronic pain lasts longer than three months, subacute pain lasts a few weeks or months, and acute pain is recent.

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